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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition Abacavir (ABC) is the most powerful nucleo Abacavir (ABC) is the most powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. (Wikipedia) Pharmacology: Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Mechanism of action: Abacavir is a carbocyclic synthetic nucleoside analogue. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-HIV Agents. Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Reverse Transcriptase Inhibitors hibitors. Reverse Transcriptase Inhibitors
Has role Drug +
Id CHEBI_2360  +
Label Abacavir  +
Modification dateThis property is a special property in this wiki. 14 April 2014 20:05:57  +
ModifiedDate 14 April 2014  +
RelatedTo Gag-Pol polyprotein +
SuperCategory Molecular entity  +
Synonym ABC  +, abacavir  +, Epzicom  +, Ziagen  +
Categories Molecular entity
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