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Category:Acamprosate
Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB00659  +
Definition Acamprosate, also known by the brand name Acamprosate, also known by the brand name Campral, is a drug used for treating alcohol dependence. Acamprosate is thought to stabilize the chemical balance in the brain that would otherwise be disrupted by alcoholism, possibly by blocking glutaminergic N-methyl-D-aspartate receptors, while gamma-aminobutyric acid type A receptors are activated. Reports indicate that acamprosate only works with a combination of attending support groups and abstinence from alcohol. Certain serious side effects include allergic reactions, irregular heartbeats, and low or high blood pressure, while less serious side effects include headaches, insomnia, and impotence. Acamprosate should not be taken by people with kidney problems or allergies to the drug. Pharmacology: Pharmacodynamic studies have shown that acamprosate calcium reduces alcohol intake in alcohol-dependent animals in a dose-dependent manner and that this effect appears to be specific to alcohol and the mechanisms of alcohol dependence. Acamprosate calcium has negligible observable central nervous system (CNS) activity in animals outside of its effects on alcohol dependence, exhibiting no anticonvulsant, antidepressant, or anxiolytic activity. Mechanism of action: The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. in vitro and in vivo studies in animals have provided evidence to suggest acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. Drug type: Approved. Investigational. Small Molecule. Drug category: Alcohol Deterrents olecule. Drug category: Alcohol Deterrents
Has role Drug +
Id CHEBI:51041  +
Label Acamprosate  +
Modification dateThis property is a special property in this wiki. 31 July 2014 23:17:38  +
ModifiedDate 31 July 2014  +
RelatedTo Glutamate (NMDA) receptor subunit 3A +, MGluR1 +, MGluR2 +, MGluR5 +, MGluR3 +
SuperCategory Molecular entity  +
Synonym 3-(Acetylamino)propanesulphonic acid  +, 3-Acetamido-1-propanesulfonic acid  +, N-Acetylhomotaurine  +, acamprosate  +, Campral  +
Categories Molecular entity
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