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Category:Acenocoumarol
Comment taken from DrugBank
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB01418  +
Definition A coumarin that is used as an anticoagulan A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Pharmacology: Acenocoumarol is a coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Mechanism of action: Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. Drug type: Approved. Small Molecule. Drug category: Anticoagulants. Coumarin and Indandione Derivatives lants. Coumarin and Indandione Derivatives
Has role Drug +
Id DB01418  +
Label Acenocoumarol  +
Modification dateThis property is a special property in this wiki. 14 April 2014 20:18:48  +
ModifiedDate 14 April 2014  +
RelatedTo Serum albumin +, Vitamin K epoxide reductase complex subunit 1 +, Alpha-1-acid glycoprotein 1 +
SuperCategory Molecular entity  +
Synonym Acenocoumarin  +, Acenocoumarolum (inn-latin)  +, Nicoumalone  +, Nicumalon  +, Nitrophenylacetylethyl-4-hydroxycoumarine  +, Nitrovarfarian  +, Nitrowarfarin  +, Ascumar  +, Neositron  +, Sincoumar  +, Sinkumar  +, Sinthrom  +, Sinthrome  +, Sintrom  +, Syncoumar  +, Syncumar  +, Syntrom  +, Zotil  +
Categories Molecular entity
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