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From NeuroLex
| Comment
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taken from DrugBank
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| CurationStatus
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uncurated +
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| Curator
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Ab +
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| DefiningCitation
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http://www.drugbank.ca/drugs/DB00414 +
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| Definition
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A sulfonylurea hypoglycemic agent that is … A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. (PubChem) Pharmacology: Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea. It lowers blood sugar by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. Acetohexamide has one-third the potency of chlorpropamide, and twice the potency of tolbutamide; however, similar hypoglycemic efficacy occurs with equipotent dosage of sulfonylureas. Mechanism of action: Sulfonylureas such as acetohexamide bind to an ATP-dependent K+ channel on the cell membrane of pancreatic beta cells. This inhibits a tonic, hyperpolarizing outflux of potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin. Drug type: Approved. Small Molecule. Drug category: Hypoglycemic Agents. Sulfonylureas tegory: Hypoglycemic Agents. Sulfonylureas
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| Has role
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Drug +
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| Id
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CHEBI_28052 +
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| Label
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Acetohexamide +
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| Modification dateThis property is a special property in this wiki.
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16 November 2010 20:25:26 +
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| ModifiedDate
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16 November 2010 +
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| RelatedTo
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ATP-sensitive inward rectifier potassium channel 1 +
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| SuperCategory
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Molecule +
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| Synonym
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Acetohexamid +,
Cyclamide +,
Dimelin +,
Dimelor +,
Dymelor +,
Gamadiabet +,
Hypoglicil +,
Metaglucina +,
Minoral +,
Ordimel +,
Tsiklamid +
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| Categories |
Molecule
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| | No properties link to this page. |
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