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Category:Acetohydroxamic Acid
Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB00551  +
Definition Acetohydroxamic Acid, a synthetic drug der Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. Pharmacology: Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. Mechanism of action: Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate. Drug type: Approved. Small Molecule. Drug category: Enzyme Inhibitors Molecule. Drug category: Enzyme Inhibitors
Has role Drug +
Id CHEBI:27777  +
Label Acetohydroxamic Acid  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:14:39  +
ModifiedDate 12 August 2014  +
RelatedTo Urease alpha subunit +, Macrophage metalloelastase +
SuperCategory Molecular entity  +
Synonym AHA  +, Acethydroxamsaure  +, Acetic acid  +, oxime  +, Acetohydroxamate  +, Acetohydroximic acid  +, Acetyl hydroxyamino  +, Acetylhydroxamic acid  +, Cetohyroxamic acid  +, Methylhydroxamic acid  +, N-Hydroxyacetamide  +, Lithostat  +
Categories Molecular entity
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