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From NeuroLex
| Comment
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taken from DrugBank
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| CurationStatus
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uncurated +
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| Curator
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Ab +
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| DefiningCitation
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http://www.drugbank.ca/drugs/DB00787 +
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| Definition
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A guanosine analog that acts as an antimet … A guanosine analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes. (PubChem) Pharmacology: Aciclovir (INN) or acyclovir (USAN, former BAN) is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of aciclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV. Mechanism of action: Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator. Drug type: Approved. Small Molecule. Drug category: Antiviral Agents. Nucleosides and Nucleotides iviral Agents. Nucleosides and Nucleotides
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| Has role
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Drug +
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| Id
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CHEBI: 2453 +
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| Label
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Aciclovir +
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| Modification dateThis property is a special property in this wiki.
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17 March 2010 02:35:39 +
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| ModifiedDate
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17 March 2010 +
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| RelatedTo
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Purine nucleoside phosphorylase +,
DNA polymerase +,
Thymidine kinase +
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| SuperCategory
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Molecule +
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| Synonym
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9-Hyroxyethoxymethylguanine +,
AC2 +,
Aciclovier +,
Aciclovir Sodium +,
Acycloguanosine +,
Acyclovir +,
Acyclovir Sodium +,
Wellcome-248u +,
Alti-Acyclovir +,
Avirax +,
Vipral +,
Virorax +,
Zovir +,
Zovirax +
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| Categories |
Molecule
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| | No properties link to this page. |
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