|
|
From NeuroLex
| Comment
|
taken from DrugBank
|
| CurationStatus
|
uncurated +
|
| Curator
|
Ab +
|
| DefiningCitation
|
http://www.drugbank.ca/drugs/DB00459 +
|
| Definition
|
An oral retinoid effective in the treatmen … An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. (PubChem) Pharmacology: Acitretin is a retinoid. Retinoids have a structure similar to vitamin A and are involved in the normal growth of skin cells. Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling. Mechanism of action: The mechanism of action of acitretin is unknown, however it is believed to work by targeting specific receptors (retinoid receptors) in the skin which help normalize the growth cycle of skin cells. Drug type: Approved. Small Molecule. Drug category: Keratolytic Agents olecule. Drug category: Keratolytic Agents
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| Has role
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Drug +
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| Id
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CHEBI_50172 +
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| Label
|
Acitretin +
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| Modification dateThis property is a special property in this wiki.
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18 November 2010 21:52:52 +
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| ModifiedDate
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18 November 2010 +
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| RelatedTo
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Retinoic acid receptor RXR-beta +,
Retinoic acid receptor gamma-1 +,
Retinoic acid receptor beta +,
Retinoic acid receptor gamma-2 +,
Retinoic acid receptor RXR-alpha +,
Serum albumin +,
Retinoic acid receptor alpha +,
Retinoic acid receptor RXR-gamma +
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| SuperCategory
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Molecule +
|
| Synonym
|
Acetretin +,
Soriatane +
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| Categories |
Molecule
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| | No properties link to this page. |
|---|
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|
