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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition Adapalene is a topical retinoid primarily Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. (Wikipedia) Pharmacology: Adapalene is a chemically stable retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Mechanism of action: Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Drug type: Approved. Small Molecule. Drug category: Anti-Inflammatory Agents, Non-Steroidal. Dermatologic Agents Agents, Non-Steroidal. Dermatologic Agents
Has role Drug +
Id CHEBI:31174  +
Label Adapalene  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:15:32  +
ModifiedDate 12 August 2014  +
RelatedTo Retinoic acid receptor RXR-beta +, Retinoic acid receptor gamma-1 +, Retinoic acid receptor beta +, Retinoic acid receptor gamma-2 +, Retinoic acid receptor RXR-alpha +, Retinoic acid receptor alpha +, Retinoic acid receptor RXR-gamma +
SuperCategory Molecular entity  +
Synonym Adapaleno (INN-Spanish)  +, Adapalenum (INN-Latin)  +, Adaferin  +, Differin  +
Categories Molecular entity
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