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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition A purine base and a fundamental unit of ad A purine base and a fundamental unit of adenine nucleotides. (PubChem) Pharmacology: Adenine (sometimes known as vitamin B4) combines with the sugar ribose to form adenosine, which in turn can be bonded with from one to three phosphoric acid units, yielding AMP, ADP and ATP . These adenine derivatives perform important functions in cellular metabolism. Adenine is one of four nitrogenous bases utilized in the synthesis of nucleic acids. A modified form of adenosine monophosphate (cyclic AMP) is an imporant secondary messenger in the propagation of many hormonal stimuli. Adenine is an integral part of the structure of many coenzymes. Adenosine (adenine with a ribose group) causes transient heart block in the AV node of the heart. In individuals suspected of suffering from a supraventricular tachycardia (SVT), adenosine is used to help identify the rhythm. Certain SVTs can be successfully terminated with adenosine. Mechanism of action: Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between reactions. In older literature, adenine was sometimes called Vitamin B4Not Available Drug type: Approved. Nutraceutical. Small Molecule. Drug category: Dietary supplement. Micronutrient ategory: Dietary supplement. Micronutrient
Has role Drug +
Id CHEBI:16708  +
Label Adenine  +
Modification dateThis property is a special property in this wiki. 31 July 2014 23:11:58  +
ModifiedDate 31 July 2014  +
RelatedTo Adenine phosphoribosyltransferase +, DNA +, S-methyl-5-thioadenosine phosphorylase +, Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase +, Ribosome-inactivating protein alpha-trichosanthin +, Ribosome-inactivating protein momordin I +, Ricin +, Antiviral protein I +, Low molecular weight phosphotyrosine protein phosphatase +, Acetyl-CoA carboxylase +, Antiviral protein S +, Uncharacterized protein YML079W +, MTA/SAH nucleosidase +, Purine trans deoxyribosylase +, Serine/threonine-protein kinase SKY1 +, A/G-specific adenine glycosylase +, Peroxisomal trans-2-enoyl-CoA reductase +, Antiviral protein DAP-30 +, Seed lectin subunit I +, Holliday junction ATP-dependent DNA helicase ruvB +
SuperCategory Molecular entity  +
Synonym 1H-Purin-6-amine  +, 6-Aminopurine  +, Adenin  +, Adeninimine  +, Vitamin B4  +, Leuco-4  +, Pedatisectine B  +
Categories Molecular entity
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