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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition Amphetamine is a chiral compound. The race Amphetamine is a chiral compound. The racemic mixture can be divided into its optical antipodes: levo- and dextro-amphetamine. Amphetamine is the parent compound of its own structural class, comprising a broad range of psychoactive derivatives, e.g., MDMA (Ecstasy) and the N-methylated form, methamphetamine. Amphetamine is a homologue of phenethylamine. Pharmacology: Amphetamine and dextroamphetamine, non-catechloamine sypathomimetic agents, are used in combination to treat attention-deficit hyperactivity disorder (ADHD) or narcolepsy. Adderall consists of equivalent amounts of amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate. Mechanism of action: Amphetamines stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems. Amphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect. Drug type: Approved. Illicit. Small Molecule. Drug category: Adrenergic Agents. Adrenergic Uptake Inhibitors. Amphetamines. Central Nervous System Stimulants. Dopamine Agents. Dopamine Uptake Inhibitors. Sympathomimetics pamine Uptake Inhibitors. Sympathomimetics
Has role Drug +, Drug of abuse role +
Id CHEBI:2679  +
Label Amphetamine  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:21:12  +
ModifiedDate 12 August 2014  +
RelatedTo Alpha2A receptor +, Alpha1A receptor +, Sodium-dependent dopamine transporter +, Cocaine- and amphetamine-regulated transcript protein +, Trace amine-associated receptor 1 +
SuperCategory Molecular entity  +
Synonym (+/-)-Benzedrine  +, (+/-)-Desoxynorephedrine  +, (+/-)-beta-Phenylisopropylamine  +, 1-Methyl-2-phenylethylamine  +, 1-Phenyl-2-aminopropane  +, 3-Methoxy-a-methylbenzeneethanamine  +, 3-Methoxyamphetamine  +, 3-Methoxyphenylisopropylamine  +, Amfetamine  +, Amphetamine Sulfate  +, DL-alpha-Methylphenethylamine  +, Fenylo-izopropylaminyl  +, Methamphetamine HCL  +, Phenylisopropylamine  +, (1-(3-Methoxyphenyl)-2-propyl)amine  +, alpha-Methylbenzeneethaneamine  +, beta-Aminopropylbenzene  +, beta-phenyl-isopropylamine  +, dl-1-Phenyl-2-aminopropane  +, dl-Amphetamine  +, dl-Benzedrine  +, m-Methoxy-a-methylphenethylamine  +, m-Methoxyamphetamine  +, Actedron  +, Adipan  +, Allodene  +, Anorexide  +, Anorexine  +, Benzebar  +, Benzedrine  +, Benzolone  +, Desoxyn  +, Dexampex  +, Dexedrine  +, Dextrostat  +, Elastonon  +, Fenamin  +, Ferndex  +, Finam  +, Isoamycin  +, Isoamyne  +, Isomyn  +, Mecodrin  +, Methampex  +, Norephedrane  +, Novydrine  +, Oktedrin  +, Ortedrine  +, Paredrine  +, Percomon  +, Phenamine  +, Phenedrine  +, Profamina  +, Propisamine  +, Psychedrine  +, Raphetamine  +, Rhinalator  +, Simpatedrin  +, Simpatina  +, Sympamin  +, Sympamine  +, Sympatedrine  +, Weckamine  +
Categories Molecular entity
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Resource:KI Biobank - Amphetamine dependence + Keywords


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