From NeuroLex
Acronym
ALS +
Created
5 October 2007 +
CurationStatus
uncurated +
DefiningCitation
Adams et al., Principles of Neurology, 6th ed, pp1089-94 +
Definition
A degenerative disorder affecting upper MO … A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). RVE ROOTS and corticospinal tracts (MeSH).
DefinitionSource
MeSH +
Id
birnlex_12566 +
Label
Amyotrophic Lateral Sclerosis +
Modification date This property is a special property in this wiki.
24 October 2009 05:13:00 +
ModifiedDate
24 October 2009 +
SuperCategory
Motor Neuron Disease +
Synonym
Lou Gehrig's Disease + ,
Gehrig's Disease + ,
Maladie de Charcot + ,
ALS +
Categories
Motor Neuron Disease
Resource:Biobank of Hospital Clinic - IDIBAPS + Resource:Blueprint Neurotherapeutics Network + Resource:Brain Research Centre + Resource:Brain Research Institute Research Resources + Resource:Brain-Net + Resource:Duke University Kathleen Price Bryan Brain Bank + Resource:Emory ADRC Tissue and Biospecimen Banking Facility + Resource:Emory Neurology Database + Resource:Harvard Brain Tissue Resource Center + Resource:Jackson Laboratory Neurobiology + Resource:MNT - Medical News Today + Resource:MassGeneral Institute for Neurodegenerative Disease + Resource:NEALS Sample Repository + Resource:NEALS: The Northeast ALS Consortium + Resource:NINDS Repository + Resource:New York Brain Bank at Columbia University + Resource:Northwestern CNADC Tissue Bank / Neuropathology Core + Resource:OHSU Brain Institute + Resource:Oregon Brain Bank + Resource:Penn Brain Bank + …
Keywords
Resource:ALS Association + Resource:Biobank of Hospital Clinic - IDIBAPS + Resource:Brain Research Centre + Resource:Brain Research Institute Research Resources + Resource:Brain-Net + Resource:Duke University Kathleen Price Bryan Brain Bank + Resource:Emory ADRC Tissue and Biospecimen Banking Facility + Resource:GWASrap + Resource:Gait Dynamics in Neuro-Degenerative Disease Data Base + Resource:Harvard Brain Tissue Resource Center + Resource:Jackson Laboratory Neurobiology + Resource:MassGeneral Institute for Neurodegenerative Disease + Resource:NEALS Sample Repository + Resource:NINDS Repository + Resource:New York Brain Bank at Columbia University + Resource:OHSU Brain Institute + Resource:Oregon Brain Bank + Resource:PatientsLikeMe + Resource:Penn Brain Bank +
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