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Category:Butorphanol
Comment taken from DrugBank
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB00611  +
Definition A synthetic morphinan analgesic with narco A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain. (PubChem) Pharmacology: Butorphanol is a synthetic opioid agonist-antagonist analgesic with a pharmacological and therapeutic profile that has been well established since its launch as a parenteral formulation in 1978. The introduction of a transnasal formulation of butorphanol represents a new and noninvasive presentation of an analgesic for moderate to severe pain. This route of administration bypasses the gastrointestinal tract, and this is an advantage for a drug such as butorphanol that undergoes significant first-pass metabolism after oral administration. The onset of action and systemic bioavailability of butorphanol following transnasal delivery are similar to those after parenteral administration. Butorphanol blocks pain impulses at specific sites in the brain and spinal cord. Mechanism of action: Butorphanol is a mixed agonist-antagonist with low intrinsic activity at receptors of the -opioid type (morphine-like). It is also an agonist at -opioid receptors. Its interactions with these receptors in the central nervous system apparently mediate most of its pharmacologic effects, including analgesia. Drug type: Approved. Illicit. Small Molecule. Drug category: Analgesics, Opioid. Antitussive Agents. Narcotic Antagonists. Narcotics ve Agents. Narcotic Antagonists. Narcotics
Has role Drug +
Id DB00611  +
Label Butorphanol  +
Modification dateThis property is a special property in this wiki. 14 April 2014 20:11:06  +
ModifiedDate 14 April 2014  +
RelatedTo Delta receptor +, Kappa-type opioid receptor +, Mu receptor +
SuperCategory Molecular entity  +
Synonym Butorfanol  +, Butorfanol (INN-Spanish)  +, Butorphanol Tartrate  +, Butorphanolum (INN-Latin)  +, Beforal  +, Moradol  +, Stadol  +, Stadol NS  +
Categories Molecular entity
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