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Category:DBA/1J
Abbrev D1  +
AbbrevSource MGI  +
Created 15 August 2007  +
CurationStatus pending_final_vetting  +
DefiningCitation Beck, J.A., et al., Genealogies of mouse inbred strains (2000), Nature, Jan2000, v24, p23  +
ExternallySourcedDefinition Type: Inbred Strain TJL Mating System: Sib Type: Inbred Strain TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: q Generation: F197 (14-DEC-06) Appearance: dilute brown Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age. Strain Description Immunization with type II collagen leads to the development of a severe polyarthritis mediated by an autoimmune response, thus DBA/1J mice are widely used as a model for rheumatoid arthritis. The incidence of collagen induced arthritis varies by experimental protocol, but is less than 100%. Similar to the human condition, mice with collagen-induced arthritis display synovitis and erosions of cartilage and bone. In addition, susceptibility in both humans and mice is linked to the expression of specific MHC class II molecules. DBA/1J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions on an atherogenic diet. In response to challenge, DBA/1J mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease (Xie et al., 2004). Strain Development The DBA inbred strain is the oldest of all inbred strains of mice. Dr. CC Little began inbreeding in 1909 from a mouse colony segregating for coat color. During 1929 and 1930 crosses were made among substrains and several new substrains established including DBA/1 and DBA/2. DBA/1 and DBA/2 differ at a large number of loci (including the MHC H2 haplotype) which is most likely due to residual heterozygosity at the separation. residual heterozygosity at the separation.
Id birnlex_389  +
Modification dateThis property is a special property in this wiki. 26 May 2009 12:38:43  +
Categories DBA
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