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Category:Delta 71-82 Alpha-Synuclein Drosophila
Authors Magali Periquet  +, Tudor Fulga  +, Liisa Myllykangas  +, Michael G. Schlossmacher  +, and Mel B. Feany  +
CurationStatus uncurated  +
Definition This transgenic drosophila expresses a for This transgenic drosophila expresses a form of alpha-synuclein with a deletion in the NAC domain that removes amino acids 71-82. This mutated alpha-synuclein is unable to aggregate in vitro in a transgenic Drosophila model. There are no alpha-synclein aggregates and no loss of tyrosine hydroxylase- positive neurons. This mutation is used to investigate the importance of alpha-synuclein aggregation on neurodegenerative diseases like Parkinson's Disease. erative diseases like Parkinson's Disease.
Figure 1-3 +
Id nlx_organ_090802  +
JournalNumber 12 +
JournalVolume 27 +
Label Delta 71-82 Alpha-Synuclein Drosophila  +
Modification dateThis property is a special property in this wiki. 28 October 2009 01:21:50  +
ModifiedDate 28 October 2009  +
PMID 17376994  +
Pages 3338-3346
PublicationDate March 21 +, 2007 +
PublicationName The Journal of Neuroscience +
Title Aggregated Alpha-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo  +
Categories Mutant Drosophila
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