From NeuroLex
| Category:Delta 71-82 Alpha-Synuclein Drosophila |
| Authors | Magali Periquet +, Tudor Fulga +, Liisa Myllykangas +, Michael G. Schlossmacher +, and Mel B. Feany + |
|---|---|
| CurationStatus | uncurated + |
| Definition | This transgenic drosophila expresses a for … This transgenic drosophila expresses a form of alpha-synuclein with a deletion in the NAC domain that removes amino acids 71-82. This mutated alpha-synuclein is unable to aggregate in vitro in a transgenic Drosophila model. There are no alpha-synclein aggregates and no loss of tyrosine hydroxylase- positive neurons. This mutation is used to investigate the importance of alpha-synuclein aggregation on neurodegenerative diseases like Parkinson's Disease. erative diseases like Parkinson's Disease. |
| Figure | 1-3 + |
| Id | nlx_organ_090802 + |
| JournalNumber | 12 + |
| JournalVolume | 27 + |
| Label | Delta 71-82 Alpha-Synuclein Drosophila + |
| Modification dateThis property is a special property in this wiki. | 28 October 2009 01:21:50 + |
| ModifiedDate | 28 October 2009 + |
| PMID | 17376994 + |
| Pages | 3338-3346 |
| PublicationDate | March 21 +, 2007 + |
| PublicationName | The Journal of Neuroscience + |
| Title | Aggregated Alpha-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo + |
| Categories | Mutant Drosophila |
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