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Category:Dextromethorphan
Abbrev DM  +
Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB00514  +
Definition The d-isomer of the codeine analog of levo The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. (PubChem) Pharmacology: Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. Mechanism of action: Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. Drug type: Approved. Small Molecule. Drug category: Analgesics, Opioid. Antitussive Agents. Excitatory Amino Acid Antagonists Agents. Excitatory Amino Acid Antagonists
Has role Drug +, Drug of abuse role +, Antagonist role +
Id CHEBI:4470  +
Label Dextromethorphan  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:22:36  +
ModifiedDate 12 August 2014  +
RelatedTo Cholinergic system +, Sigma 1-type opioid receptor +, Opioid receptor +, Sigma 1 +, Glutamate (NMDA) receptor subunit 3A +, Neuronal acetylcholine receptor subunit alpha-2 +, Sodium-dependent serotonin transporter +, Alpha 3 Acetylcholine Receptor +
SuperCategory Molecular entity  +
Synonym D-Methorphan  +, D-Methorphan Hydrobromide  +, Delta-Methorphan  +, Demorphan  +, Demorphan Hydrobromide  +, Demorphine  +, Destrometerfano (Dcit)  +, Dextromethorfan (Czech)  +, Dextromethorphan Bromhydrate  +, Dextromethorphan Bromide  +, Dextrometorfano (INN-Spanish)  +, Dextrometorphan  +, Dextromorphan  +, Dexyromethorphan  +, L-Methorphan  +, Levomethorphan  +, Levomethorphan (Ban:Dcf:Inn)  +, Levomethorphane (INN-French)  +, Levomethorphanum (INN-Latin)  +, Levometorfano (INN-Spanish)  +, Antussan  +, Balminil DM  +, Benylin DM  +, Calmylin  +, Canfodion  +, Cosylan  +, Creo-Terpin  +, Delsym  +, Dormetan  +, Dormethan  +, Hihustan M  +, Koffex DM  +, Medicon  +, Methorate Hydrobromide  +, Methorphan  +, Metrorat  +, Novahistex DM  +, Novahistine DM  +, Pertussin  +, Pertussin DM  +, Robitussin  +, Romilar  +, Triaminic DM  +, Trocal  +, Tusilan  +, Tussade  +, Vicks 44  +
Categories Molecular entity
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Alpha 3 Acetylcholine Receptor + RelatedTo
 

 

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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.