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Category:Dopamine
Abbrev DA  +
Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB00988  +
Definition One of the catecholamine neurotransmitters One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. (PubChem) Pharmacology: Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Mechanism of action: Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings. Drug type: Approved. Small Molecule. Drug category: Cardiotonic Agents. Dopamine Agents. Sympathomimetic. Sympathomimetics Agents. Sympathomimetic. Sympathomimetics
Has role Drug +, Neurotransmitter +, Excitatory neurotransmitter +, Inhibitory neurotransmitter +
Id CHEBI:18243  +
Label Dopamine  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:21:23  +
ModifiedDate 12 August 2014  +
RelatedTo D1 receptor +, Dopamine beta-hydroxylase +, Beta1 receptor +, Dopaminergic system +, Catecholamine system +
SuperCategory Molecular entity  +
Synonym Deoxyepinephrine  +, Dopamin  +, Dopamine HCl  +, Dophamine  +, Hydroxytyramin  +, Hydroxytyramine  +, Oxytyramine  +, Intropin  +, Revimine  +
Categories Molecular entity
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Resource:Mouse Party +, Resource:NeuroMouse Database + Keywords
Aplysia buccal 20 +, Olfactory bulb (accessory) glomerular layer cell +, Olfactory bulb (main) periglomerular cell +, Olfactory tubercle Islets of Calleja DA cell +, Retina amacrine cell +, Substantia nigra pars compacta dopaminergic cell +, Ventral tegmental area dopamine neuron + Neurotransmitter
Mauthner cell +, Mushroom body (Honey bee) Kenyon cell +, Neocortex basket cell + NeurotransmitterReceptors
Aromatic L-Amino Acid Decarboxylase +, D Dopa +, D1 receptor +, D2 receptor +, D3 receptor +, D4 receptor +, D5 receptor +, Dopamine beta-hydroxylase +, Dopamine receptor +, Levodopa +, Tyrosine Hydroxylase +, Ventral tegmental area + RelatedTo
 

 

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