arrow

From NeuroLex

Jump to: navigation, search
Category:FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse
CurationStatus graph position temporary  +
Curator Maryann Martone +
Definition Mutant mouse strain that harbors two trans Mutant mouse strain that harbors two transgenic alleles and a single targeted mutant. The Tg(SMN2*delta7)4299Ahmb allele consists of a SMA cDNA lacking exon 7 whereas the Tg(SMN2)89Ahmb allele consists of the entire human SMN2 gene. Mice that are homozygous for the targeted mutant Smn allele and homozygous for the two transgenic alleles exhibit symptoms and neuropathology similar to patients afflicted with proximal spinal muscular atrophy (SMA) (from Jackson Laboratories MGI mouse resource: http://jaxmice.jax.org/strain/005025.html) http://jaxmice.jax.org/strain/005025.html)
Has improper value forThis property is a special property in this wiki. DefiningCitation  +
Id nlx_10066  +
Label FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse  +
Modification dateThis property is a special property in this wiki. 19 April 2011 01:52:52  +
ModifiedDate 19 April 2011  +
PMID 15703193  +
PublicationLink http://www.ncbi.nlm.nih.gov/pubmed/15703193?dopt=Abstract  +
SuperCategory Mutant mouse strain  +
Synonym delta 7 SMA mouse  +
Categories Mutant mouse strain
hide properties that link here 
  No properties link to this page.
 

 

Enter the name of the page to start browsing from.