From NeuroLex
| Category:FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse |
| CurationStatus | graph position temporary + |
|---|---|
| Curator | Maryann Martone + |
| Definition | Mutant mouse strain that harbors two trans … Mutant mouse strain that harbors two transgenic alleles and a single targeted mutant. The Tg(SMN2*delta7)4299Ahmb allele consists of a SMA cDNA lacking exon 7 whereas the Tg(SMN2)89Ahmb allele consists of the entire human SMN2 gene. Mice that are homozygous for the targeted mutant Smn allele and homozygous for the two transgenic alleles exhibit symptoms and neuropathology similar to patients afflicted with proximal spinal muscular atrophy (SMA) (from Jackson Laboratories MGI mouse resource: http://jaxmice.jax.org/strain/005025.html) http://jaxmice.jax.org/strain/005025.html) |
| Has improper value forThis property is a special property in this wiki. | DefiningCitation + |
| Id | nlx_10066 + |
| Label | FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse + |
| Modification dateThis property is a special property in this wiki. | 19 April 2011 01:52:52 + |
| ModifiedDate | 19 April 2011 + |
| PMID | 15703193 + |
| PublicationLink | http://www.ncbi.nlm.nih.gov/pubmed/15703193?dopt=Abstract + |
| SuperCategory | Mutant mouse strain + |
| Synonym | delta 7 SMA mouse + |
| Categories | Mutant mouse strain |
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