Neurolex is being transitioned to a new system and is currently not accepting new additions. If you have additions or questions please contact us at [email protected], or submit an issue to the github issue tracker at


From NeuroLex

Jump to: navigation, search
Comment taken from DrugBank
Curator Ab +
DefiningCitation  +
Definition Fenfluramine was withdrawn from the U.S. m Fenfluramine was withdrawn from the U.S. market in 1997 after reports of heart valve disease and pulmonary hypertension, including a condition known as cardiac fibrosis. Pharmacology: Used to treat diabetes and obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain's synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes. Mechanism of action: Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Drug type: Illicit. Small Molecule. Withdrawn. Drug category: Anorexigenic Agents. Serotonin Agonists. Serotonin reuptake inhibitor. Stimulants . Serotonin reuptake inhibitor. Stimulants
Has role Drug +
Id DB00574  +
Label Fenfluramine  +
Modification dateThis property is a special property in this wiki. 14 April 2014 19:52:55  +
ModifiedDate 14 April 2014  +
RelatedTo 5-hydroxytryptamine 2B receptor +, 5-hydroxytryptamine 2C receptor +
SuperCategory Molecular entity  +
Synonym DEA No  +, 1670  +, Fenfluramina (DCIT)  +, Fenfluramine Hydrochloride  +, Fenfluraminum (INN-Latin)  +, Acino  +, Adipomin  +, Obedrex  +, Pesos  +, Ponderax Pa  +, Ponderex  +, Pondimin  +, Rotondin  +
Categories Molecular entity
hide properties that link here 
  No properties link to this page.


Enter the name of the page to start browsing from.

*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.