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Comment taken from DrugBank
Curator Ab +
DefiningCitation  +
Definition Fludarabine (marketed as fludarabine phosp Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. (Wikipedia) Pharmacology: Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. Mechanism of action: Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. Drug type: Approved. Small Molecule. Drug category: Antimetabolites. Antimetabolites, Antineoplastic. Antineoplastic Agents. Immunosuppressive Agents eoplastic Agents. Immunosuppressive Agents
Has role Drug +
Id DB01073  +
Label Fludarabine  +
Modification dateThis property is a special property in this wiki. 14 April 2014 20:07:39  +
ModifiedDate 14 April 2014  +
RelatedTo Apoptosis regulator Bcl-2 +, Ribonucleoside-diphosphate reductase large subunit +, DNA polymerase alpha catalytic subunit +, Signal transducer and activator of transcription 1-alpha/beta +, Adenosine deaminase +
SuperCategory Molecular entity  +
Synonym FAMP  +, Fludarabine 5'-monophosphate  +, Fludarabine monophosphate  +, Fludarabine phosphate  +, Fludara  +, Fludura  +
Categories Molecular entity
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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.