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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition Flupentixol is an antipsychotic neurolepti Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist. Pharmacology: Flupenthixol is an anxiolytic, antidepressive agent and a mood stabilizer. It inhibits the central monoamine receptors, particularly the dopamine D1 and D2 receptors. Therefore, it increases the amount of serotonin and noradrenaline that control mood and thinking, and improves mood. Mechanism of action: Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists. Thioxanthenes otics. Dopamine Antagonists. Thioxanthenes
Has role Drug +
Id CHEBI:5121  +
Label Flupenthixol  +
Modification dateThis property is a special property in this wiki. 31 July 2014 23:17:47  +
ModifiedDate 31 July 2014  +
RelatedTo D1 receptor +, Alpha1A receptor +, D1 dopamine receptor-interacting protein calcyon +, D2 receptor +, Multidrug resistance protein 1 +
SuperCategory Molecular entity  +
Synonym Flupenthixole  +, Depixol  +, Emergil  +, Fluanxol  +, Fluanxol Depot  +, Flupentixol  +, Flurentixol  +, Fluxanxol  +, Siplaril  +, Siplarol  +
Categories Molecular entity
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