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Category:Glibenclamide
Comment taken from DrugBank
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB01016  +
Definition An antidiabetic sulfonylurea derivative wi An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. (PubChem) Pharmacology: Glibenclamide (INN), also known as glyburide (USAN), a second-generation sulfonylurea antidiabetic agent, appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonyl-urea hypoglycemic drugs. The combination of glibenclamide and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different but complementary mechanisms. In addition to its blood glucose lowering actions, glibenclamide produces a mild diuresis by enhancement of renal free water clearance. Glibenclamide is twice as potent as the related second-generation agent glipizide. Mechanism of action: Sulfonylureas such as glibenclamide likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. Drug type: Approved. Small Molecule. Drug category: Antiarrhythmic Agents. Hypoglycemic Agents. Sulfonylureas Agents. Hypoglycemic Agents. Sulfonylureas
Has role Drug +
Id DB01016  +
Label Glibenclamide  +
Modification dateThis property is a special property in this wiki. 14 April 2014 20:22:01  +
ModifiedDate 14 April 2014  +
RelatedTo ATP-binding cassette sub-family A member 1 +, ATP-binding cassette transporter sub-family C member 8 +, ATP-binding cassette transporter sub-family C member 9 +, ATP-sensitive inward rectifier potassium channel 1 +, Bile salt export pump +, ATP-sensitive inward rectifier potassium channel 11 +, Multidrug resistance-associated protein 1 +, Canalicular multispecific organic anion transporter 2 +, Cystic fibrosis transmembrane conductance regulator +, G protein-activated inward rectifier potassium channel 4 +
SuperCategory Molecular entity  +
Synonym Apo-Glibenclamide  +, Glibenclamida (INN-Spanish)  +, Glibenclamidum (INN-Latin)  +, Glyburide  +, Abbenclamide  +, Adiab  +, Azuglucon  +, Bastiverit  +, Benclamin  +, Betanase  +, Betanese 5  +, Calabren  +, Cytagon  +, Daonil  +, Debtan  +, Dia-basan  +, Diabeta  +, Diabiphage  +, Dibelet  +, Duraglucon  +, Euclamin  +, Euglucan  +, Euglucon  +, Euglucon 5  +, Euglykon  +, GBN 5  +, Gen-Glybe  +, Gewaglucon  +, Gilemal  +, Glamide  +, Glibadone  +, Gliban  +, Gliben  +, Gliben-Puren N  +, Glibenbeta  +, Glibenclamid AL  +, Glibenclamid Basics  +, Glibenclamid Fabra  +, Glibenclamid Genericon  +, Glibenclamid Heumann  +, Glibenclamid Riker M  +, Glibenclamid-Cophar  +, Glibenclamid-Ratiopharm  +, Glibenil  +, Glibens  +, Glibesyn  +, Glibet  +, Glibetic  +, Glibil  +, Gliboral  +, Glicem  +, Glidiabet  +, Glimel  +, Glimide  +, Glimidstata  +, Glisulin  +, Glitisol  +, Glubate  +, Gluben  +, Gluco-Tablimen  +, Glucobene  +, Glucohexal  +, Glucolon  +, Glucomid  +, Glucoremed  +, Glucoven  +, Glyben  +, Glybenclamide  +, Glybenzcyclamide  +, Glycolande  +, Glycomin  +, Glynase  +, Hexaglucon  +, Humedia  +, Lederglib  +, Libanil  +, Lisaglucon  +, Malix  +, Maninil  +, Med-Glionil  +, Melix  +, Micronase  +, Miglucan  +, Nadib  +, Neogluconin  +, Norglicem 5  +, Normoglucon  +, Novo-Glyburide  +, Orabetic  +, Pira  +, Praeciglucon  +, PresTab  +, Prodiabet  +, Renabetic  +, Semi-Daonil  +, Sugril  +, Suraben  +, Tiabet  +, Yuglucon  +
Categories Molecular entity
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