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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition An oral sulfonylurea hypoglycemic agent wh An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion. (PubChem) Pharmacology: Gliclazide is a second generation sulphonylurea which acts as a hypoglycemic agent. It stimulates beta cells of the islet of Langerhans in the pancreas to release insulin. It also enhances peripheral insulin sensitivity. Overall it potentiates insulin release and improves insulin dynamics. Mechanism of action: Gliclazide binds to the beta cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the beta cells. This opens voltage-dependent calcium channels in the beta cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. Drug type: Approved. Small Molecule. Drug category: Hypoglycemic Agents. Sulfonylureas tegory: Hypoglycemic Agents. Sulfonylureas
Has role Drug +
Id CHEBI:31654  +
Label Gliclazide  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:19:22  +
ModifiedDate 12 August 2014  +
RelatedTo Vascular endothelial growth factor A +, ATP-binding cassette transporter sub-family C member 8 +, Serum albumin +, ATP-sensitive inward rectifier potassium channel 1 +
SuperCategory Molecular entity  +
Synonym 1-(3-Azabicyclo(3  +, 3  +, 0)oct-3-yl)-3-(p-tolylsulfonyl)urea  +, 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea  +, Gliclazida (INN-Spanish)  +, Gliclazidum (INN-Latin)  +, N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3  +, 0)oct-3-yl)urea  +, Diamicron  +, Glimicron  +, Nordialex  +
Categories Molecular entity
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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.