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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition A non-essential amino acid. It is found pr A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. (PubChem) Pharmacology: Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system. Mechanism of action: In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia. Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS. Drug type: Approved. Nutraceutical. Small Molecule. Drug category: Dietary supplement. Glycine Agents. Micronutrient. Non-Essential Amino Acids . Micronutrient. Non-Essential Amino Acids
Has role Drug +, Inhibitory neurotransmitter +
Id CHEBI:15428  +
Label Glycine  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:23:08  +
ModifiedDate 12 August 2014  +
RelatedTo Glycine receptor subunit beta +, Alanine--glyoxylate aminotransferase 2 +, Mitochondrial +, Glutathione synthetase +, Serine hydroxymethyltransferase +, Serine--pyruvate aminotransferase +, Cytosolic +, Glycine amidinotransferase +, Glycine N-methyltransferase +, 5-aminolevulinate synthase +, Nonspecific +, Glycine receptor subunit alpha-3 +, Glycine receptor subunit alpha-1 +, Glutamate (NMDA) receptor subunit epsilon-3 +, 2-amino-3-ketobutyrate coenzyme A ligase +, Glutamate (NMDA) receptor subunit 3B +, Proton-coupled amino acid transporter 1 +, Glycine dehydrogenase (decarboxylating) +, Glycine receptor subunit alpha-2 +, Glutamate (NMDA) receptor subunit epsilon-1 +, Erythroid-specific +, Sodium- and chloride-dependent glycine transporter 1 +, Glycyl-tRNA synthetase +, Serine hydroxymethyltransferase 2 +, SHMT2 protein +, Hypothetical protein DKFZp686P09201 +, Glycine cleavage system H protein +, Bile acid CoA:amino acid N-acyltransferase +, N-arachidonyl glycine receptor +, Glycine N-acyltransferase +, Glycine N-acyltransferase-like protein 2 +, Glycine N-acyltransferase-like protein 1 +, Vesicular inhibitory amino acid transporter +, Peroxisomal sarcosine oxidase +, Sodium- and chloride-dependent glycine transporter 2 +
SuperCategory Amino Acid  +
Synonym 2-Aminoacetic acid  +, Aminoacetic acid  +, Aminoethanoic acid  +, Gly  +, Aciport  +, Glicoamin  +, Glycocoll  +, Glycolixir  +, Glycosthene  +, Gyn-Hydralin  +, Padil  +
Categories Amino Acid
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Resource:IconBAZAAR +, Resource:Ligand-Gated Ion Channel Database +, Resource:NeuroMouse Database + Keywords
Cochlear nucleus (ventral) multipolar D cell + MolecularConstituents
Cochlear nucleus (dorsal) cartwheel cell +, Cochlear nucleus (dorsal) vertical cell +, Cochlear nucleus (ventral) multipolar D cell +, Retina amacrine cell +, Spinal cord ventral horn interneuron Renshaw +, Trapezoid body medial nucleus principal cell + Neurotransmitter


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