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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition A vesicant and necrotizing irritant destru A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. (PubChem) Pharmacology: Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from toxic gas warfare research. It belongs to the group of nitrogen mustard alkylating agents. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. Mechanism of action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Mechlorethamine is cell cycle phase-nonspecific. Drug type: Approved. Small Molecule. Drug category: Alkylating Agents. Antineoplastic Agents, Alkylating. Chemical Warfare Agents. Irritants lating. Chemical Warfare Agents. Irritants
Has role Drug +
Id CHEBI:28925  +
Label Mechlorethamine  +
Modification dateThis property is a special property in this wiki. 31 July 2014 23:13:48  +
ModifiedDate 31 July 2014  +
RelatedTo DNA +
SuperCategory Molecular entity  +
Synonym Chlorethazine  +, Chlormethine  +, HN2  +, MBA  +, Mechloroethamine  +, Mecloretamina  +, Mustine  +, Nitrogen mustard  +, Caryolysin  +, Caryolysine  +, Cloramin  +, Dichloren  +, Embichin  +, Mustargen  +, Mutagen  +
Categories Molecular entity
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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.