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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition A biguanide hypoglycemic agent used in the A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289) Pharmacology: Metformin is an antihyperglycemic agent, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and daylong plasma insulin response may actually decrease. Mechanism of action: Metformin's pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Drug type: Approved. Small Molecule. Drug category: Hypoglycemic Agents lecule. Drug category: Hypoglycemic Agents
Has role Drug +
Id CHEBI:6801  +
Label Metformin  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:19:26  +
ModifiedDate 12 August 2014  +
RelatedTo 5'-AMP-activated protein kinase subunit beta-1 +
SuperCategory Molecular entity  +
Synonym Metformin HCL  +, metformin hydrochloride  +, Apo-Metformin  +, Fortamet  +, Gen-Metformin  +, Glucophage  +, Glucophage XR  +, Glycon  +, Novo-Metformin  +, Nu-Metformin  +, Riomet  +
Categories Molecular entity
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Resource:Diabetes Prevention Program +, Resource:Diabetes Prevention Program Outcomes Study +, Resource:Nonalcoholic Steatohepatitis Clinical Research Network +, Resource:Open Medicine Live Wiki +, Resource:Treatment Options for type 2 Diabetes in Adolescents and Youth + Keywords


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