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Category:Phenobarbital
Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation http://www.drugbank.ca/drugs/DB01174  +
Definition A barbituric acid derivative that acts as A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. (PubChem) Pharmacology: Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). Mechanism of action: Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal. Drug type: Approved. Small Molecule. Drug category: Anticonvulsants. Excitatory Amino Acid Antagonists. GABA Modulators. Hypnotics and Sedatives . GABA Modulators. Hypnotics and Sedatives
Has role Drug +, Drug of abuse role +
Id CHEBI:8069  +
Label Phenobarbital  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:22:28  +
ModifiedDate 12 August 2014  +
RelatedTo GABRA1 +
SuperCategory Molecular entity  +
Synonym Fenobarbital  +, Phenobarbitol  +, Phenobarbituric Acid  +, Phenylethylbarbiturate  +, Phenylethylbarbituric Acid  +, Phenylethylmalonylurea  +, Adonal  +, Aephenal  +, Agrypnal  +, Amylofene  +, Aphenylbarbit  +, Aphenyletten  +, Barbenyl  +, Barbinal  +, Barbiphen  +, Barbiphenyl  +, Barbipil  +, Barbita  +, Barbivis  +, Barbonal  +, Barbophen  +, Bardorm  +, Bartol  +, Bialminal  +, Blu-Phen  +, Cabronal  +, Calmetten  +, Calminal  +, Cardenal  +, Chinoin  +, Codibarbita  +, Coronaletta  +, Cratecil  +, Damoral  +, Dezibarbitur  +, Dormina  +, Dormiral  +, Dormital  +, Doscalun  +, Duneryl  +, Ensobarb  +, Ensodorm  +, Epanal  +, Epidorm  +, Epilol  +, Episedal  +, Epsylone  +, Eskabarb  +, Etilfen  +, Euneryl  +, Fenbital  +, Fenemal  +, Fenosed  +, Fenylettae  +, Gardenal  +, Gardepanyl  +, Glysoletten  +, Haplopan  +, Haplos  +, Helional  +, Hennoletten  +, Henotal  +, Hypnaletten  +, Hypnette  +, Hypno-Tablinetten  +, Hypnogen  +, Hypnolone  +, Hypnoltol  +, Hysteps  +, Lefebar  +, Leonal  +, Lephebar  +, Lepinal  +, Lepinaletten  +, Linasen  +, Liquital  +, Lixophen  +, Lubergal  +, Lubrokal  +, Lumen  +, Lumesettes  +, Lumesyn  +, Luminal  +, Lumofridetten  +, Luphenil  +, Luramin  +, Molinal  +, Neurobarb  +, Nirvonal  +, Noptil  +, Nova-Pheno  +, Nunol  +, Parkotal  +, Pharmetten  +, Phen-Bar  +, Phenaemal  +, Phenemal  +, Phenemalum  +, Phenobal  +, Phenobarbyl  +, Phenoluric  +, Phenolurio  +, Phenomet  +, Phenonyl  +, Phenoturic  +, Phenyletten  +, Phenyral  +, Phob  +, Polcominal  +, Promptonal  +, Seda-Tablinen  +, Sedabar  +, Sedicat  +, Sedizorin  +, Sedlyn  +, Sedofen  +, Sedonal  +, Sedonettes  +, Sevenal  +, Sinoratox  +, Solfoton  +, Solfoton Talpheno  +, Solu-Barb  +, Sombutol  +, Somnolens  +, Somnoletten  +, Somnosan  +, Somonal  +, Spasepilin  +, Starifen  +, Starilettae  +, Stental  +, Stental Extentabs  +, Talpheno  +, Teolaxin  +, Teoloxin  +, Thenobarbital  +, Theoloxin  +, Triabarb  +, Tridezibarbitur  +, Triphenatol  +, Versomnal  +, Zadoletten  +, Zadonal  +
Categories Molecular entity
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