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From NeuroLex
| Comment
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taken from DrugBank
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| CurationStatus
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uncurated +
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| Curator
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Ab +
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| DefiningCitation
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http://www.drugbank.ca/drugs/DB01174 +
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| Definition
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A barbituric acid derivative that acts as … A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. (PubChem) Pharmacology: Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). Mechanism of action: Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal. Drug type: Approved. Small Molecule. Drug category: Anticonvulsants. Excitatory Amino Acid Antagonists. GABA Modulators. Hypnotics and Sedatives . GABA Modulators. Hypnotics and Sedatives
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| Has role
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Drug +,
Drug of abuse role +
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| Id
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CHEBI_8069 +
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| Label
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Phenobarbital +
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| Modification dateThis property is a special property in this wiki.
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16 November 2010 00:09:12 +
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| ModifiedDate
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16 November 2010 +
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| RelatedTo
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GABRA1 +
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| SuperCategory
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Molecular entity +
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| Synonym
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Fenobarbital +,
Phenobarbitol +,
Phenobarbituric Acid +,
Phenylethylbarbiturate +,
Phenylethylbarbituric Acid +,
Phenylethylmalonylurea +,
Adonal +,
Aephenal +,
Agrypnal +,
Amylofene +,
Aphenylbarbit +,
Aphenyletten +,
Barbenyl +,
Barbinal +,
Barbiphen +,
Barbiphenyl +,
Barbipil +,
Barbita +,
Barbivis +,
Barbonal +,
Barbophen +,
Bardorm +,
Bartol +,
Bialminal +,
Blu-Phen +,
Cabronal +,
Calmetten +,
Calminal +,
Cardenal +,
Chinoin +,
Codibarbita +,
Coronaletta +,
Cratecil +,
Damoral +,
Dezibarbitur +,
Dormina +,
Dormiral +,
Dormital +,
Doscalun +,
Duneryl +,
Ensobarb +,
Ensodorm +,
Epanal +,
Epidorm +,
Epilol +,
Episedal +,
Epsylone +,
Eskabarb +,
Etilfen +,
Euneryl +,
Fenbital +,
Fenemal +,
Fenosed +,
Fenylettae +,
Gardenal +,
Gardepanyl +,
Glysoletten +,
Haplopan +,
Haplos +,
Helional +,
Hennoletten +,
Henotal +,
Hypnaletten +,
Hypnette +,
Hypno-Tablinetten +,
Hypnogen +,
Hypnolone +,
Hypnoltol +,
Hysteps +,
Lefebar +,
Leonal +,
Lephebar +,
Lepinal +,
Lepinaletten +,
Linasen +,
Liquital +,
Lixophen +,
Lubergal +,
Lubrokal +,
Lumen +,
Lumesettes +,
Lumesyn +,
Luminal +,
Lumofridetten +,
Luphenil +,
Luramin +,
Molinal +,
Neurobarb +,
Nirvonal +,
Noptil +,
Nova-Pheno +,
Nunol +,
Parkotal +,
Pharmetten +,
Phen-Bar +,
Phenaemal +,
Phenemal +,
Phenemalum +,
Phenobal +,
Phenobarbyl +,
Phenoluric +,
Phenolurio +,
Phenomet +,
Phenonyl +,
Phenoturic +,
Phenyletten +,
Phenyral +,
Phob +,
Polcominal +,
Promptonal +,
Seda-Tablinen +,
Sedabar +,
Sedicat +,
Sedizorin +,
Sedlyn +,
Sedofen +,
Sedonal +,
Sedonettes +,
Sevenal +,
Sinoratox +,
Solfoton +,
Solfoton Talpheno +,
Solu-Barb +,
Sombutol +,
Somnolens +,
Somnoletten +,
Somnosan +,
Somonal +,
Spasepilin +,
Starifen +,
Starilettae +,
Stental +,
Stental Extentabs +,
Talpheno +,
Teolaxin +,
Teoloxin +,
Thenobarbital +,
Theoloxin +,
Triabarb +,
Tridezibarbitur +,
Triphenatol +,
Versomnal +,
Zadoletten +,
Zadonal +
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| Categories |
Molecular entity
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| | No properties link to this page. |
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