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From NeuroLex
| Comment
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taken from DrugBank
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| CurationStatus
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uncurated +
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| Curator
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Ab +
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| DefiningCitation
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http://www.drugbank.ca/drugs/DB00777 +
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| Definition
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Propiomazine, an atypical antipsychotic ag … Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. Pharmacology: Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. Mechanism of action: Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Propiomazine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Propiomazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Drug type: Approved. Small Molecule. Drug category: Sedatives and Hypnotics le. Drug category: Sedatives and Hypnotics
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| Has role
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Drug +
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| Id
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CHEBI: 8491 +
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| Label
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Propiomazine +
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| Modification dateThis property is a special property in this wiki.
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29 October 2010 06:25:28 +
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| ModifiedDate
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29 October 2010 +
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| RelatedTo
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Cholinergic system +,
D1 receptor +,
M3 receptor +,
M1 receptor +,
M5 receptor +,
D4 receptor +,
M4 receptor +,
H1 receptor +,
5-hydroxytryptamine 2A receptor +,
Alpha1A receptor +,
5-hydroxytryptamine 2C receptor +,
M2 receptor +,
Alpha1B receptor +,
Alpha1D receptor +,
D2 receptor +
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| SuperCategory
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Molecule +
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| Synonym
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Largon +,
Phenoctyl +,
Propiomazina (INN-Spanish) +,
Propiomazine (Usan:Ban:Inn) +,
Propiomazinum (INN-Latin) +,
Propionylpromethazine +
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| Categories |
Molecule
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| | No properties link to this page. |
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