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Comment taken from DrugBank
CurationStatus uncurated  +
Curator Ab +
DefiningCitation  +
Definition A widely used non-cardioselective beta-adr A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. (PubChem) Pharmacology: Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity. Mechanism of action: Like atenolol and metoprolol, propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles. Drug type: Approved. Investigational. Small Molecule. Drug category: Adrenergic Agents. Adrenergic beta-Antagonists. Anti-Arrhythmia Agents. Anti-anxiety Agents. Antiarrhythmic Agents. Antihypertensive Agents. Vasodilator Agents ntihypertensive Agents. Vasodilator Agents
Has role Drug +
Id CHEBI:8499  +
Label Propranolol  +
Modification dateThis property is a special property in this wiki. 12 August 2014 00:17:24  +
ModifiedDate 12 August 2014  +
RelatedTo Beta1 receptor +, 5-hydroxytryptamine 1A receptor +, Beta2 receptor +, 5-hydroxytryptamine 1B receptor +, Beta3 receptor +
SuperCategory Molecular entity  +
Synonym Dl-Propranolol Hydrochloride  +, Propanalol  +, Propanolol  +, Propranalol  +, Propranolol Hcl  +, Propranolol Hydrochloride  +, R  +, S-Propranolol Hydrochloride  +, propranolol  +, Angilol  +, Apsolol  +, Avlocardyl  +, Bedranol  +, Beprane  +, Berkolol  +, Beta-Neg  +, Beta-Propranolol  +, Beta-Tablinen  +, Beta-Timelets  +, Betachron  +, Betalong  +, Cardinol  +, Caridolol  +, Corpendol  +, Deralin  +, Dociton  +, Duranol  +, Efektolol  +, Elbrol  +, Etalong  +, Euprovasin  +, Frekven  +, Inderal  +, Inderal La  +, Inderide  +, Indobloc  +, Innopran XL  +, Intermigran  +, Kemi S  +, Migrastat  +, Obsidan  +, Oposim  +, Prano-Puren  +, Propanix  +, Prophylux  +, Propranolol Hcl Intensol  +, Propranur  +, Proprasylyt  +, Pylapron  +, Rapynogen  +, Reducor  +, Reducor Line  +, Sagittol  +, Servanolol  +, Sloprolol  +, Sumial  +, Tesnol  +
Categories Molecular entity
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*Note: Neurolex imports many terms and their ids from existing community ontologies, e.g., the Gene Ontology. Neurolex, however, is a dynamic site and any content beyond the identifier should not be presumed to reflect the content or views of the source ontology. Users should consult with the authoritative source for each ontology for current information.