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Category:Resource:A Whole Genome Admixture Scan for Type 2 Diabetes in African Americans
Availability Genome scan is available for download as CSV +
CurationStatus uncurated  +
DefiningCitation http://www.broad.mit.edu/node/549  +
Definition Genomic data set on Type 2 Diabetes in Afr Genomic data set on Type 2 Diabetes in African-Americans derived via admixture mapping, a method for genome-wide association analysis based on admixture-generated linkage disequilibrium. This collaborative group has identified 1,478 African Americans with Type 2 Diabetes (T2D) from the Jackson Heart Study and Multiethnic Cohort Study, as well as 498 controls from the Jackson Heart Study who are normoglycemic despite high body mass index and older age. All samples were genotyped (using the Illumina BeadLab platform) for 1,291 polymorphic markers chosen to be extremely different in frequency between west Africans and European Americans. Evidence for association to diabetes at each marker as reported by the ANCESTRYMAP software are reported in the downloadable table.<br /> They calculate that this study has statistical power to detect loci where African or European ancestry on average confers multiplicative increased risk of 1.35-fold or more. The fact that they did not detect a statistically significant signal of association in the scan suggests that any genetic risk factors for T2D do not confer different risks due to ancestry that differ by this factor.<br /> The genome scan results are publicly available (Excel file) prior to publication so that researchers interested in the genetics of T2D can use the results of the scan to prioritize follow-up of any regions of interest. tize follow-up of any regions of interest.
Has default formThis property is a special property in this wiki. Resource  +
Has role Data set +
Id nif-0000-30020  +
Is part of Massachusetts Institute of Technology; Massachusetts; USA +
Keywords Admixture +, Genome +, GWAS +, Disequilibrium +, Normoglycemic +, Genotyped +, Polymorphic +, Marker +, Diabetes +, Clinical study +, Phenotype +, African American +, Aging +
Label Resource:A Whole Genome Admixture Scan for Type 2 Diabetes in African Americans  +
Modification dateThis property is a special property in this wiki. 8 July 2014 16:24:44  +
ModifiedDate 8 July 2014  +
Page has default formThis property is a special property in this wiki. Resource  +
RelatedTo Jackson Heart Study +
Related disease Diabetes +
SuperCategory Resource  +
Supporting Agency Eli and Edythe L. Broad +
Synonym Diabetes Genetics Initiative  +
Categories Resource
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