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Category:Resource:Binding Mother of All Databases
Abbrev Binding MOAD  +
Address Bioinformatics Graduate Program  +, Biophysics Research Division  +, University of Michigan  +, Ann Arbor  +, MI 48109  +, Torrey Path LLC  +, MI 48104  +, USA.  +
Availability Free +, Public +, Acknowledgement requested +
CurationStatus curated  +
DefiningCitation  +
Definition Database of protein-ligand crystal structu Database of protein-ligand crystal structures that is a subset of the Protein Data Bank (PDB), containing every high-quality example of ligand-protein binding. The resolved protein crystal structures with clearly identified biologically relevant ligands are annotated with experimentally determined binding data extracted from literature. A viewer is provided to examine the protein-ligand structures. Ligands have additional chemical data, allowing for cheminformatics mining. The binding-affinity data ranges 13 orders of magnitude. The issue of redundancy in the data has also been addressed. To create a nonredundant dataset, one protein from each of the 1780 protein families was chosen as a representative. Representatives were chosen by tightest binding, best resolution, etc. For the 1780 "best" complexes that comprise the nonredundant version of Binding MOAD, 475 (27%) have binding data. This collection of protein-ligand complexes will be useful in elucidating the biophysical patterns of molecular recognition and enzymatic regulation. The complexes with binding-affinity data will help in the development of improved scoring functions and structure-based drug discovery techniques. structure-based drug discovery techniques.
ExampleImage Binding MOAD.PNG +
Grant Category:MCB 0546073   +
Has default formThis property is a special property in this wiki. Resource  +
Has role Database +
Id nif-0000-21048  +
Is part of University of Michigan; Michigan; USA +
Keywords Drug +, Enzymatic +, Affinity +, Binding +, Binding-affinity +, Biological +, Chemical +, Cheminformatic +, Crystal +, Crystallography +, Intermolecular interaction +, Signaling pathway +, Ligand +, Protein +, Ligand-protein binding +, Protein crystal structure +, Protein-ligand +, Protein-ligand complex +
Label Resource:Binding MOAD  +
Listedby Resource:OMICtools +, Resource:3DVC +
Modification dateThis property is a special property in this wiki. 11 December 2014 15:51:30  +
ModifiedDate 11 December 2014  +
PMID 18055497, 16168689, 15971202  +
Page has default formThis property is a special property in this wiki. Resource  +
RelatedTo Resource:PDB +
SuperCategory Resource  +
Supporting Agency Resource:Arnold and Mabel Beckman Foundation +
Synonym  +, Binding Mother of All Databases  +
Xref OMICS_01900  +
Categories Resource
redirect page Resource:Binding MOAD
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Resource:Drug Design Data Resource + Uses


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