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Comment taken from DrugBank
Curator Ab +
DefiningCitation  +
Definition A racemic mixture with a 1:1 ratio of the A racemic mixture with a 1:1 ratio of the r-isomer, levalbuterol, and s-albuterol. It is a short-acting beta2-adrenergic agonist with its main clinical use in asthma. (PubChem) Pharmacology: Salbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity. The R-enantiomer is sold in its pure form as Levalbuterol. The manufacturer of levalbuterol, Sepracor, has implied (although not directly claimed) that the presence of only the R-enantiomer produces fewer side-effects. Mechanism of action: Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation. Increased intracellular cyclic AMP concentrations also cause an inhibition of the release of mediators from mast cells in the airways. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Agonists. Bronchodilator Agents. Tocolytic Agents s. Bronchodilator Agents. Tocolytic Agents
Has role Drug +
Id DB01001  +
Label Salbutamol  +
Modification dateThis property is a special property in this wiki. 14 April 2014 20:25:39  +
ModifiedDate 14 April 2014  +
RelatedTo Beta2 receptor +, Interleukin-8 +
SuperCategory Molecular entity  +
Synonym Albuterol  +, Albuterol Sulfate  +, Albuterol Sulphate  +, Levalbuterol  +, Salbutamol Sulfate  +, Salbutamol Sulphate  +, Accuneb  +, Aerolin  +, Airomir  +, Asmaven  +, Asmol  +, Asthalin  +, Asthavent  +, Broncovaleas  +, Buventol  +, Cetsim  +, Cobutolin  +, Ecovent  +, Loftan  +, ProAir  +, Proventil  +, Rotahaler  +, Salamol  +, Salbulin  +, Salbutard  +, Salbutine  +, Salbuvent  +, Solbutamol  +, Sultanol  +, Venetlin  +, Ventalin Inhaler  +, Ventolin  +, Ventolin Inhaler  +, Ventolin Rotacaps  +, Volma  +, Volmax  +, Xopenex  +
Categories Molecular entity
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