]> 2013-05-23T08:37:03-07:00 Carprofen taken from DrugBank http://www.drugbank.ca/drugs/DB00821 Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal pain and nausea, similar to those recorded with aspirin and other non-steroidal anti-inflammatory drugs. It is no longer marketed for human usage, after being withdrawn on commercial grounds. (Wikipedia) Pharmacology: Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. It is no longer used in the clinical setting, but is approved for use in dogs. Carprofen is non-narcotic and has characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models. Mechanism of action: The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. In an in vitro study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1. Drug type: Approved. Small Molecule. Drug category: Anti-Inflammatory Agents, Non-Steroidal. Photosensitizing Agents DB00821 Carprofen 2010-02-05T00:00:00 Molecule 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid 6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid 6-Chloro-alpha-methylcarbazole-2-acetic acid Carprofene (inn-french) Carprofeno (inn-spanish) Carprofenum (inn-latin) Ridamyl Rimadyl Molecule Synonym SuperCategory Prostaglandin G/H synthase 2 RelatedTo ModifiedDate Label Id Drug Has role Definition DefiningCitation Ab Curator Comment