]> 2013-05-20T13:27:58-07:00 Nateglinide taken from DrugBank http://www.drugbank.ca/drugs/DB00731 Nateglinide is an amino-acid derivative that lowers blood glucose levels by stimulating insulin secretion from the pancreas. This action is dependent upon functioning beta-cells in the pancreatic islets. Pharmacology: Nateglinide is an amino-acid derivative that lowers blood glucose levels by stimulating insulin secretion from the pancreas. This action is dependent upon functioning beta-cells in the pancreatic islets. Mechanism of action: Nateglinide interacts with the ATP-sensitive potassium (K+ATP) channel on pancreatic beta-cells. The subsequent depolarization of the beta cell opens the calcium channel, producing calcium influx and insulin secretion. The extent of insulin release is glucose dependent and diminishes at low glucose levels. Nateglinide is highly tissue selective with low affinity for heart and skeletal muscle. Drug type: Approved. Investigational. Small Molecule. Drug category: Hypoglycemic Agents. Meglitinides DB00731 Nateglinide 2010-02-04T00:00:00 Molecule Nateglinide (INN) SDZ-DJN 608 nateglinide Fastic Starlix Starsis Molecule Synonym SuperCategory ATP-sensitive inward rectifier potassium channel 11 ATP-sensitive inward rectifier potassium channel 1 ATP-binding cassette transporter sub-family C member 8 RelatedTo ModifiedDate Label Id Drug Has role Definition DefiningCitation Ab Curator Comment