]> 2013-05-24T06:35:41-07:00 Phenobarbital taken from DrugBank uncurated http://www.drugbank.ca/drugs/DB01174 A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. (PubChem) Pharmacology: Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). Mechanism of action: Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal. Drug type: Approved. Small Molecule. Drug category: Anticonvulsants. Excitatory Amino Acid Antagonists. GABA Modulators. Hypnotics and Sedatives CHEBI_8069 Phenobarbital 2010-11-16T00:00:00 Molecular entity Fenobarbital Phenobarbitol Phenobarbituric Acid Phenylethylbarbiturate Phenylethylbarbituric Acid Phenylethylmalonylurea Adonal Aephenal Agrypnal Amylofene Aphenylbarbit Aphenyletten Barbenyl Barbinal Barbiphen Barbiphenyl Barbipil Barbita Barbivis Barbonal Barbophen Bardorm Bartol Bialminal Blu-Phen Cabronal Calmetten Calminal Cardenal Chinoin Codibarbita Coronaletta Cratecil Damoral Dezibarbitur Dormina Dormiral Dormital Doscalun Duneryl Ensobarb Ensodorm Epanal Epidorm Epilol Episedal Epsylone Eskabarb Etilfen Euneryl Fenbital Fenemal Fenosed Fenylettae Gardenal Gardepanyl Glysoletten Haplopan Haplos Helional Hennoletten Henotal Hypnaletten Hypnette Hypno-Tablinetten Hypnogen Hypnolone Hypnoltol Hysteps Lefebar Leonal Lephebar Lepinal Lepinaletten Linasen Liquital Lixophen Lubergal Lubrokal Lumen Lumesettes Lumesyn Luminal Lumofridetten Luphenil Luramin Molinal Neurobarb Nirvonal Noptil Nova-Pheno Nunol Parkotal Pharmetten Phen-Bar Phenaemal Phenemal Phenemalum Phenobal Phenobarbyl Phenoluric Phenolurio Phenomet Phenonyl Phenoturic Phenyletten Phenyral Phob Polcominal Promptonal Seda-Tablinen Sedabar Sedicat Sedizorin Sedlyn Sedofen Sedonal Sedonettes Sevenal Sinoratox Solfoton Solfoton Talpheno Solu-Barb Sombutol Somnolens Somnoletten Somnosan Somonal Spasepilin Starifen Starilettae Stental Stental Extentabs Talpheno Teolaxin Teoloxin Thenobarbital Theoloxin Triabarb Tridezibarbitur Triphenatol Versomnal Zadoletten Zadonal Molecular entity Synonym SuperCategory GABRA1 RelatedTo ModifiedDate Label Id Drug of abuse role Drug Has role Definition DefiningCitation Ab Curator CurationStatus Comment