]> 2013-05-25T20:16:07-07:00 Resource:Temporal-Lobe: Hippocampal - Parahippocampal Neuroanatomy of the Rat curated http://www.temporal-lobe.com/ This resource is a set of tables, which show the connections to and from various subfields of the hippocampus. It includes references for each connection.<br /> Many researchers that study the hippocampus have made their own attempt at drawing a diagram of the connections in the hippocampus. When attempting this, one soon discovers that it is challenging to create a diagram that accurately resembles the literature. Natalie Cappaert and Niels van Strien too started this project as an attempt to increase their own understanding of the network. Soon they discovered that creating a diagram of the hippocampal - parahippocampal connections with all its topological detail is indeed a complex task. They started in 2005 and worked together with an expert in the field, Prof. Dr. Menno P. Witter. Although many additions are conceivable, the first version of their interactive diagram is now finalized and available for download. It displays almost 1600 connections in the rat hippocampal - parahippocampal region, which can all be interactively switched on and off. In addition, a Nature Reviews Neuroscience paper is available in which the anatomy is reviewed with an emphasis on underexposed connections in the network, and some of the functional implications of these connections.<br /> In order to comprehend the unique functional contribution of each parahippocampal - hippocampal sub-region, detailed anatomical knowledge is of pivotal importance. In the diagram featured on this website, they attempted to visualize the three-dimensional organization of the projection patterns between and within the parahippocampal region and hippocampal formation. All literature concerning projections of this system for the rat (see References) was collected and reported projections were stored in a database. Over the years, the nomenclature has changed and when necessary reported results were translated into a common frame of reference using this table). Subsequently, almost 1600 projections were drawn between all subdivisions of the HF and PHR with as much topographical detail as current knowledge permits.<br /> Converging evidence suggests that encoding, consolidation and retrieval of declarative memories rely on interactions between the hippocampal formation and the parahippocampal region. Anatomical studies established that these areas consist of eight sub-regions, which form multiple, intricately connected networks. Current functional thinking does not fully take the improved under-standing of the circuitry into consideration. Here, they integrate existing knowledge into an interactive diagram in which any connection can be turned on or off at the level of cortical layers, which helps neuroscientists to conceive this complex network. The primary project aims are: - To provide an overview of all known anatomical projections of the rat hippocampal - parahippocampal network. - To provide a graphical interface with which users can turn on or off any connections at regional level down to the level of cortical layers. - To make it easy to find references for a particular projection.<br /> nif-0000-24805 Resource:Temporal-Lobe: Hippocampal - Parahippocampal Neuroanatomy of the Rat 2012-06-05T00:00:00 Resource TEMPORAL-LOBE Parahippocampal-hippocampal network Parahippocampal hippocampal connectivity Temporal-lobe.com Resource:Rat Hippocampus Atlas Resource:NIF Integrated Manually Extracted Annotation Resource:NIF Integrated Nervous System Connectivity View Resource Synonym Various independent donations Research Council of Norway Supporting Agency SuperCategory Rat Species Resource:NIF Data Federation RelatedTo PublicationLink ModifiedDate Label Connectome Brain connectivity Topological Temporal lobe Subfield Projection Parahippocampal Neuroscience Neuroanatomy Literature Layer Hippocampus Hippocampal Diagram Cortical Connection Anatomical Function Keywords Norwegian University of Science and Technology; Trondheim; Norway Is part of Id Database Has role File:Temporallobecom.png ExampleImage Definition DefiningCitation CurationStatus