]> 2013-05-22T21:26:35-07:00 Salbutamol taken from DrugBank http://www.drugbank.ca/drugs/DB01001 A racemic mixture with a 1:1 ratio of the r-isomer, levalbuterol, and s-albuterol. It is a short-acting beta2-adrenergic agonist with its main clinical use in asthma. (PubChem) Pharmacology: Salbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity. The R-enantiomer is sold in its pure form as Levalbuterol. The manufacturer of levalbuterol, Sepracor, has implied (although not directly claimed) that the presence of only the R-enantiomer produces fewer side-effects. Mechanism of action: Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation. Increased intracellular cyclic AMP concentrations also cause an inhibition of the release of mediators from mast cells in the airways. Drug type: Approved. Small Molecule. Drug category: Adrenergic beta-Agonists. Bronchodilator Agents. Tocolytic Agents DB01001 Salbutamol 2010-02-05T00:00:00 Molecule Albuterol Albuterol Sulfate Albuterol Sulphate Levalbuterol Salbutamol Sulfate Salbutamol Sulphate Accuneb Aerolin Airomir Asmaven Asmol Asthalin Asthavent Broncovaleas Buventol Cetsim Cobutolin Ecovent Loftan ProAir Proventil Rotahaler Salamol Salbulin Salbutard Salbutine Salbuvent Solbutamol Sultanol Venetlin Ventalin Inhaler Ventolin Ventolin Inhaler Ventolin Rotacaps Volma Volmax Xopenex Molecule Synonym SuperCategory Interleukin-8 Beta2 receptor RelatedTo ModifiedDate Label Id Drug Has role Definition DefiningCitation Ab Curator Comment